N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
N6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions.RNA m6A modification is regulated by two groups of cellular proteins, writers and erasers that add or remove m6A, respectively.HIV-1 RNA contains m6A modifications that modulate viral infection and gene expression in CD4+